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  • Title: Quantification of n-alkanes in stratum corneum in the hereditary ichthyoses.
    Author: Judge MR, Morse-Fisher N, Manku M, Harper JI.
    Journal: Br J Dermatol; 1992 Aug; 127(2):91-6. PubMed ID: 1390160.
    Abstract:
    Chromatographic assay of n-alkanes in skin showed detectable levels in normal controls and in patients with various forms of hereditary ichthyosis. Raised n-alkanes were found in some, but not all, patients with non-bullous and bullous ichthyosiform erythroderma and in individual patients with lamellar ichthyosis, ichthyosis vulgaris and Netherton's syndrome. The finding of elevated scale n-alkanes is neither consistent in ichthyosis, nor specific to any one type of ichthyosis, and n-alkane assay is not helpful in distinguishing one type of hereditary ichthyosis from another. The source of n-alkanes in ichthyotic scale and their role, if any, in the pathogenesis of ichthyosis remain obscure.
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