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  • Title: [Radioimmunological determination of unconjugated plasma estradiol and estriol after administration of dehydroepiandrosterone sulfate in late pregnancy].
    Author: Schollberg K, Seiler E, Holtorff J, Köhler B.
    Journal: Zentralbl Gynakol; 1976; 98(25):1537-46. PubMed ID: 139062.
    Abstract:
    In 16 normal and pathologic pregnancies we carried out the dehydroepiandrosterone-sulphate loading test by injection of 50 mg DHEA-S-Na intravenously. The plasma concentrations of unconjugated estradiol and estriol were measured by radioimmun-assay. The level of estradiol increased continuously, rising to a maximum 60 min after the injection. In pre-eclamptic patients and cases of intrauterine growth retardation the rise was significantly reduced. There was a good correlation between result of the test and clinical dates. In plasma concentrations of unconjugated estriol no changes could be observed within 3 hours after the injection.
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