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  • Title: [Successes in studying the physiological activity of terpenoids and steroids].
    Author: Paseshnichenko VA.
    Journal: Biokhimiia; 1992 Jul; 57(7):986-1003. PubMed ID: 1391217.
    Abstract:
    Data concerning the structure and function of prenyl proteins and peptides of fungi and animals are reviewed. There exist proteins that are posttranslationally modified by thioether-linked farnesyl- or geranylgeranyl groups; the modification affects the cysteine residue near the C-terminus. Prenylation increases hydrophobicity and is expected to promote protein binding to membrane lipids or other hydrophobic proteins. Isopentenyl-adenylated proteins mediate isoprenoid control over DNA synthesis and are involved in regulation of cell proliferation in animals. Sterols of fungi and plants play a role in regulation of the membrane structure as well as in proliferation. The significance biologically active terpenoids for biotechnology, medicine, and agriculture is discussed.
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