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  • Title: The effect of corticotrophin and corticosteroids on the external secretion of the pancreas in dogs.
    Author: SIRCUS W.
    Journal: Gut; 1961 Dec; 2(4):338-45. PubMed ID: 13913433.
    Abstract:
    In acute experiments in dogs cortisone and hydrocortisone increase the concentration and output of bicarbonate in pancreatic secretion whereas prolonged administration of these hormones leads to a diminished bicarbonate response. In both acute and chronic experiments, however, cortisone and hydrocortisone produce an increased output of the enzymes amylase and trypsin.
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