These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Potential risks of high-dose adrenaline for resuscitation following short-term heart arrest in animal experiments].
    Author: Hörnchen U, Berg PW, Schüttler J.
    Journal: Anasthesiol Intensivmed Notfallmed Schmerzther; 1992 Aug; 27(5):274-8. PubMed ID: 1391364.
    Abstract:
    We compared the haemodynamic effects of epinephrine 10 micrograms/kg iv (group A, n = 8) and 50 micrograms/kg iv (group B, n = 8) in a porcine CPR-model after 3 min of circulatory arrest induced by ventricular fibrillation. All animals of group A were successfully resuscitated after 4.9 +/- 2.8 min and 2.8 +/- 1.6 defibrillations, in group B only 6 of 8 animals were successfully resuscitated after 6.3 +/- 1.1 min and 4.0 +/- 2.7 defibrillations (Mean +/- SD). Cardiac output, left ventricular systolic pressure and mean arterial pressure during CPR were nearly identical in both groups. The first hour of restored spontaneous circulation in group B was characterised by a significantly increased heart rate combined with significantly lower values for cardiac inotropy, cardiac output, left ventricular systolic pressure and mean arterial pressure. It is concluded that in acute or short-term cardiac arrest the currently recommended epinephrine dosages are sufficient. Higher doses of epinephrine for CPR seem to be recommendable only after prolonged cardiac arrest and/or during prolonged resuscitation.
    [Abstract] [Full Text] [Related] [New Search]