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  • Title: Role of thromboxane in mediating the intrarenal vasoconstriction induced by unmodified stroma free hemoglobin in the isolated perfused rat kidney.
    Author: Lieberthal W, LaRaia J, Valeri CR.
    Journal: Biomater Artif Cells Immobilization Biotechnol; 1992; 20(2-4):663-7. PubMed ID: 1391492.
    Abstract:
    Unmodified stroma free hemoglobin (SFH) increased renal vascular resistance (RVR) from 4.0 +/- 0.2 to 6.9 +/- 0.9 mmHg/ml/min in control isolated kidneys. In kidneys obtained from rats pretreated with the thromboxane synthetase inhibitor OKY-046 RVR increased from 3.9 +/- 0.3 to 4.8 +/- 0.4 mmHg/ml/min. The percent increase in RVR was greater in response to SFH in control kidneys (67 +/- 14%) than in OKY-046 treated kidneys (23 +/- 7%)(p less than 0.05). SFH resulted in a fall in glomerular filtration rate (GFR) from 0.75 +/- 0.09 to 0.21 +/- 0.04 ml/min in control kidneys while in kidneys from OKY-046 treated rats GFR fell from 0.65 +/- 0.04 to 0.54 +/- 0.06 ml/min. The percent fall in GFR was greater in vehicle treated kidneys (69 +/- 8%) as opposed to OKY-046 treated kidneys (19 +/- 7%)(p less than 0.05). The rate of urinary thromboxane excretion measured before the addition of SFH to the perfusate was 52 pg/min in the control group and 7 pg/min in the OKY-046 treated group(p less than 0.05).
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