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  • Title: [Biochemical bases of ftorafur-potentiating effects of perfluorodecalin, inducer of cytochrome P-450 dependent microsomal monooxygenases].
    Author: Khlopushina TG, Krinskaia AV, Bukhman VM, Zherdev VP, Val'dman AV.
    Journal: Biull Eksp Biol Med; 1992 Jan; 113(1):35-8. PubMed ID: 1391859.
    Abstract:
    Activity of cytochrome P-450-dependent monooxygenase system is significantly lower in hepatoma H-2-73 and Lewis lung carcinoma-bearing mice as compared to that in control animals. An inhibition of the cytochrome P-450 system was observed after the injection of ftorafur. Treatment of the mice with perfluorodecalin markedly increased the antineoplastic activity of ftorafur determined by a loss of the leucocytes and of the weight hepatoma H-2-73- and Lewis lung carcinoma resistant to ftorafur alone.
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