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  • Title: [Role of hematopoietic cells-precursors in the regeneration of hematopoiesis after cytostatic action].
    Author: Bogdashin IV, Buznik DV, Dygaĭ AM, Gol'dberg ED.
    Journal: Biull Eksp Biol Med; 1992 Jan; 113(1):50-1. PubMed ID: 1391864.
    Abstract:
    Cyclophosphamide was injected at a dose of 150 mg/kg once to CBA mice and caused expressed hypoplasia of bone marrow hemopoiesis (decreased myelokaryocyte count, CFU-S and CFU-D) from day 1 of the experiment. The rise of CFU-S (8) and CFU-S (12) to a baseline level was noted on day 4 (the time of intensive regeneration processes), whereas CFU-D levels did not change. It is suggested that cytostatic action may trigger "shunt" hemopoiesis mechanisms which enhance differentiation of primitive hemopoietic cells and proliferative activity of mature hemopoietic elements.
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