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  • Title: Antigenicity of polypeptides: immunological unresponsiveness to copolymers of gamma-amino acids.
    Author: MAURER PH, LOWY R, KIERNEY C.
    Journal: Science; 1963 Mar 15; 139(3559):1061-2. PubMed ID: 13933993.
    Abstract:
    Immunological tolerance toward three synthetic random copolymers of the alpha-amino acids, glutamic, lysine, alanine, and tyrosine, was produced by a single injection of the polymers into newborn rabbits. The tolerant state could be extended by an additional intravenous injection of antigen. Repeated injections of the polymer in adjuvant mixture could "break" the tolerant state.
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