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  • Title: Management of papillary carcinoma arising in thyroglossal-duct anlage.
    Author: Maziak D, Borowy ZJ, Deitel M, Jaksic T, Ralph-Edwards A.
    Journal: Can J Surg; 1992 Oct; 35(5):522-5. PubMed ID: 1393869.
    Abstract:
    Cysts of the thyroglossal duct are common congenital abnormalities. They present as asymptomatic midline cervical swellings. The risk of malignant change is low; only 103 cases have been reported in the world literature, 85% of which were papillary adenocarcinomas. The appropriate treatment for this condition remains controversial. The authors describe three patients who had papillary carcinoma contained within a thyroglossal-duct rest. All were treated by cyst resection and thyroid suppression, but without thyroidectomy and radioactive thyroid ablation. Postoperatively, all patients remained disease free, with no recurrence at follow-up ranging from 10 to 29 years. Isolated papillary carcinomas arising from primitive thyroid remnants, associated with a palpably normal thyroid gland at surgery and a negative thyroid scan, can be treated adequately by excising the thyroglossal mass.
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