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  • Title: Poisoning by organic phosphorus pesticides potentiated by phenothiazine derivatives.
    Author: GAINES TB.
    Journal: Science; 1962 Dec 14; 138(3546):1260-1. PubMed ID: 13946141.
    Abstract:
    Repeated administration of the phenothiazine derivatives chlorpromazine and promazine increased the toxicity of a single dose of parathion in male rats. In female rats, a single dose of 5 mg/kg of promazine increased the toxicity of a single dose of parathion, but had no apparent effect on the toxicity of a single dose of Phosdrin. Repeated dosage with chlorpromazine and atropine, or promazine and atropine, after administration of parathion at the same rate, resulted in a slightly higher mortality in female rats than did atropine or no treatment.
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