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  • Title: Reversible vasospasm in association with the use of heparin and dihydroergotamine.
    Author: Bachner EJ, Konsens RM, Priem L, King T, Froimson AI.
    Journal: Clin Orthop Relat Res; 1992 Oct; (283):261-4. PubMed ID: 1395256.
    Abstract:
    A case of reversible vasospasm is reported in a 54-year-old man with a closed bimalleolar ankle fracture. On admission the patient had normal distal pulses and laboratory studies. He was a heavy smoker who continued to smoke in the hospital. Deep venous thrombosis (DVT) prophylaxis included dihydroergotamine and heparin (DHE-H). In the early postoperative period, marked spasm of all three arteries developed on the operative side. Smoking privileges and DHE-H were discontinued. The vasospasm resolved after intraarterial nitroglycerin. This case suggests an infrequent but potentially limb-threatening complication of DHE-H.
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