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  • Title: Induction of cystatin S in rat submandibular glands by papain.
    Author: Naito Y, Suzuki I, Hasegawa S.
    Journal: Comp Biochem Physiol B; 1992 Aug; 102(4):861-5. PubMed ID: 1395514.
    Abstract:
    1. Papain (a cysteine proteinase) were administered into the oral cavity of rats twice daily for 5 days. This treatment caused a dramatic increase in the level of cystatin S (a cysteine proteinase inhibitor belonging to family 2 of cystatin superfamily) in enlarged submandibular glands. 2. Immunochemical analysis using antibody against rat cystatin S and electrophoretic analysis confirmed that the protein induced by papain was identical to that induced by isoproterenol. 3. Induction of the cystatin S in the submandibular glands by oral administration of papain suggested a biological response which plays a role in preventing injury exogenous proteinase.
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