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  • Title: Chronic arsenic poisoning masquerading as Landry-Guillain-Barré syndrome.
    Author: Goddard MJ, Tanhehco JL, Dau PC.
    Journal: Electromyogr Clin Neurophysiol; 1992 Sep; 32(9):419-23. PubMed ID: 1396293.
    Abstract:
    Acute arsenic intoxication may present as Landry-Guillain-Barré syndrome because of similarities in clinical symptoms involving the gastrointestinal tract, weakness, and sensory symptoms. Electrodiagnostic findings may be similar with demyelinating changes predominating early in both diseases. A case is presented of repeated arsenic poisoning over two years misdiagnosed as Landry-Guillain-Barré syndrome. Proximal F-loop latency (M-wave latency at wrist + F-wave latency at wrist - 2 M-wave latency at axilla) helped to establish the correct diagnosis. Serial electrodiagnostic studies were done documenting the evolution of chronic repeated arsenic poisoning from a picture showing demyelination to one with severe axonal loss.
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