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  • Title: High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire.
    Author: van Es JH, Meyling FH, Logtenberg T.
    Journal: Eur J Immunol; 1992 Oct; 22(10):2761-4. PubMed ID: 1396981.
    Abstract:
    Nucleotide sequence analysis of cDNA encoded by the single member of the human immunoglobulin VH6 gene family show that blood B cells in adults, but not in neonates, frequently express somatically mutated IgM molecules. The number of mutations in VH6-encoded cDNA from adult blood ranged from 2 to 19 mutations/VH gene (average 10.1/VH gene). The distribution of silent and replacement mutations suggests that at least some of the VH6 genes were derived from B cells that were activated and selected by antigen. We conclude that the blood B cell repertoire in adult humans, in contrast to its much-studied murine splenic counterpart, is a rich source of highly mutated IgM molecules.
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