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  • Title: 8-OH-DPAT-induced inhibition of renal sympathetic nerve activity and serotonin neuronal firing.
    Author: Ramage AG, Clement ME, McCall RB.
    Journal: Eur J Pharmacol; 1992 Aug 14; 219(1):165-7. PubMed ID: 1397044.
    Abstract:
    The effects of the 5-HT1A receptor 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) administered i.v. on medullary 5-HT neuronal firing and renal sympathetic nerve activity were determined in spontaneously breathing anaesthetized cats. Low doses of 8-OH-DPAT (1-3 micrograms/kg) caused a similar reduction in 5-HT neuronal firing and renal nerve activity while high doses (10-30 micrograms/kg) completely inhibited neuronal firing but caused only 80% inhibition of renal nerve activity. These data are discussed in relationship to the mechanism of sympatholytic action of 8-OH-DPAT and the serotonergic regulation of sympathetic nerve activity.
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