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  • Title: [Characterization of thyroglobulin in a patient with functioning and non-functioning benign thyroid tumors].
    Author: Ishikita T, Iino Y, Ishida T, Takei H, Morishita Y, Tarutani O.
    Journal: Nihon Naibunpi Gakkai Zasshi; 1992 Aug 20; 68(8):773-82. PubMed ID: 1397386.
    Abstract:
    The chemical and immunological properties of thyroglobulin (Tg) in tissue obtained from a patient co-existed with two types of thyroid tumors, i.e., functioning and non-functioning, and were compared with the properties of Tg that was isolated from adjacent peripheral tissue. In the present observations, the Tg content was markedly increased in the non-functioning thyroid tumor. On the other hand, the Tg content in the functioning tumor was at the normal level. The iodine content of Tg was significantly lower in the non-functioning tumor than in peripheral tissues. Affinity with Lectins differed among Tg preparations, suggesting that the carbohydrate chain in the Tg was different in each nodule in a single individual.
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