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  • Title: The effect of L-carnitine on cholesterol metabolism in rat (Rattus bubalus) hepatocyte cells.
    Author: Mondola P, Santillo M, De Mercato R, Santangelo F.
    Journal: Int J Biochem; 1992 Jul; 24(7):1047-50. PubMed ID: 1397497.
    Abstract:
    1. This paper concerns the study of the effect of L-carnitine on cholesterol metabolism in rat hepatocyte cells BRL-3A. In this research the binding of [125I]human low density lipoprotein (LDL) to BRL-3A cells and 3-hydroxy 3-methylglutaryl CoA reductase activity (HMG-CoA reductase activity) after L-carnitine incubation were studied. 2. It was found that L-carnitine is able to increase either the [125I]LDL binding or inhibit the HMG-CoA reductase activity in BRL-3A cells. 3. These results indicate that L-carnitine affects the cholesterol metabolism through an inhibition of HMG-CoA reductase activity that could be responsible for the increased [125I]LDL binding in rat hepatocytes.
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