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  • Title: Comparisons of Bence-Jones proteins and L polypeptide chains of myeloma globulins after hydrolysis with trypsin.
    Author: SCHWARTZ JH, EDELMAN GM.
    Journal: J Exp Med; 1963 Jul; 118(1):41-53. PubMed ID: 13987374.
    Abstract:
    L polypeptide chains of myeloma globulin and Bence-Jones protein isolated from the same patient were found to be identical after comparison of their tryptic hydrolysates by two-dimensional high voltage electrophoresis. The patterns of peptides from proteins belonging to antigenic group I differed markedly from those of proteins in antigenic group II. A partially purified H chain fraction was compared with L chains from the same myeloma protein. The tryptic hydrolysates yielded dissimilar patterns of peptides. These data indicate that gamma-myeloma proteins contain two kinds of polypeptide chains, Hgamma chains and either L(I) or L(II) chains. The L chains appear to be identical with those comprising the Bence-Jones protein from the same patient.
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