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  • Title: [Effect of tetanus toxin and colchicine on synaptic membranes of rat cerebral cortex].
    Author: Kryzhanovskiĭ GN, Sandalov IuG, Rodina VI, Rozhanets VV, Glebov RN.
    Journal: Biull Eksp Biol Med; 1977 Feb; 83(2):139-42. PubMed ID: 139951.
    Abstract:
    It was shown that purified tetanus toxin did not influence the activity of the Na, K-ATP-ase fractions of the synaptic membranes of the rat cerebral cortex, it had no effect on the inhibition of Na, K,-ATP-ase under electrical stimulation of the synaptic membrane suspension, or the GABA--3H binding by the synaptosomes in vitro. Tetanus toxin (400--4000 DLM) and colchicine (1 mM) induced a decrease of osmotic sensitivity of the nerve endings. Colchicine in low concentrations (10(-5)-10(-3) M) failed to influence Mg-and Na, K-ATP-ases, but considerably inhibited both ATP-ases at higher concentrations.
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