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  • Title: Centrally acting muscle relaxants in tetanus.
    Author: WEBSTER RA.
    Journal: Br J Pharmacol Chemother; 1961 Dec; 17(3):507-18. PubMed ID: 14005498.
    Abstract:
    The anti-tetanus activity of a number of phenothiazine derivatives and other centrally acting muscle relaxants, such as mephenesin, dicyclopropyl ketoxime, 2-amino-6-methylbenzothiazole and meprobamate, has been determined in rabbits with experimental local tetanus. Structure-activity relationships were obtained for the phenothiazine derivatives and their anti-tetanus activity correlated with other central and peripheral properties. Both dicyclopropyl ketoxime and 2-amino-6-methyl-benzothiazole were twice as active as mephenesin. Meprobamate does not appear to be primarily a muscle relaxant of the mephenesin type.
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