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  • Title: Comparison of two extraction procedures for urinary organic acids prior to gas chromatography-mass spectrometry.
    Author: Mardens Y, Kumps A, Planchon C, Wurth C.
    Journal: J Chromatogr; 1992 Jun 10; 577(2):341-6. PubMed ID: 1400765.
    Abstract:
    We have compared a new isolation procedure for urinary organic acids using strong anion-exchange columns with a solvent partition (ethyl acetate) method. Urinary samples from two healthy children and from nine children with organic acidurias were analysed by both procedures. Although the solid-phase extraction is more efficient for polyhydroxy acids, some polar acids, and some glycine derivatives, clinically important compounds such as oxalic, methylcitric, pyruvic, glyoxylic and 2-ketoglutaric acids, are not recovered or are only poorly recovered. However, both procedures may be used as a routine method for the diagnosis of the organic acidurias included in this study.
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