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  • Title: Differential effects of cyclosporine and etretinate on serum cytokine levels in patients with psoriasis.
    Author: Shiohara T, Imanishi K, Sagawa Y, Nagashima M.
    Journal: J Am Acad Dermatol; 1992 Oct; 27(4):568-74. PubMed ID: 1401309.
    Abstract:
    BACKGROUND: The in vivo effects of cyclosporine and etretinate on the immune system are still unclear. OBJECTIVE: Our purpose was to determine the effects of these drugs on in vivo production of various cytokines. METHODS: Serum cytokine levels were measured sequentially by radioimmunoassay in psoriasis patients treated with either cyclosporine or etretinate. RESULTS: Interferon-gamma levels were initially elevated and rapidly returned to baseline levels before clinical improvement in both treatment groups. A transient increase before the relapse was also observed in some patients. Etretinate treatment resulted in a substantial decrease in tumor necrosis factor-alpha levels, whereas an unpredictable increase was found during the late phase of cyclosporine treatment. CONCLUSION: The in vivo effects of antipsoriatic drugs on cytokine production are different from those demonstrated in vitro. Measurement of serum cytokine levels is useful for monitoring patients with psoriasis.
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