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  • Title: Myelination of regenerated axons in goldfish optic nerve by Schwann cells.
    Author: Nona SN, Duncan A, Stafford CA, Maggs A, Jeserich G, Cronly-Dillon JR.
    Journal: J Neurocytol; 1992 Jun; 21(6):391-401. PubMed ID: 1403004.
    Abstract:
    This study uses immunohistochemistry and EM to examine the site of injury in goldfish optic nerve during axonal regeneration. Within seven days of nerve crush axons begin to regrow and a network of GFAP+ reactive astrocytes appears in the nerve on either side of the injury. However, the damaged area remains GFAP-. By 42 days after nerve crush, the sheaths of new axons acquire myelin marker 6D2, and the crush area becomes populated by a mass of longitudinally-orientated S-100+ cells. Ultrastructurally, the predominant cells in the crush area bear a strong resemblance to peripheral nerve Schwann cells; they display a one-to-one association with myelinated axons, have a basal lamina and are surrounded by collagen fibres. It is proposed that these cells are Schwann cells which enter the optic nerve as a result of crush, where they become confined to the astrocyte-free crush area.
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