These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Purine modulation of prostaglandin F2 alpha (PGF2 alpha)-induced premature luteolysis in vivo in nonpregnant sheep.
    Author: Weems CW, Weems YS, Lee CN, Vincent DL.
    Journal: Second Messengers Phosphoproteins; 1992; 14(1-2):1-9. PubMed ID: 1403846.
    Abstract:
    In two separate experiments, control and PGF2 alpha-treated unilaterally ovariectomized ewes received vehicle or adenosine every four hours through an exteriorized catheter installed either to parafuse the ovarian vascular pedicle of the remaining ovary containing a corpus luteum (CL) or to infuse intrauterine ipsilateral to the remaining ovary with the CL. Infusions were given every four hours from day 7 through day 22 postestrus or until ewes returned to estrus. Chronic infusion of vehicle intrauterine or parafusion of the ovarian vascular pedicle with vehicle in PGF2 alpha-treated ewes shortened the interestrous interval compared to controls (P less than 0.05). However, chronic parafusion of the ovarian vascular pedicle with adenosine in PGF2 alpha-treated ewes prevented a PGF2 alpha-induced premature luteolysis (P less than 0.05) but not when adenosine was infused chronically intrauterine (P greater than 0.05). It is concluded that adenosine can block a PGF2 alpha-induced premature luteolysis in vivo and may have roles in regulation of luteal secretion of progesterone but it is probably not the embryonic antiluteolysin of early pregnancy in ewes.
    [Abstract] [Full Text] [Related] [New Search]