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  • Title: SEA syndrome revisited: a longterm followup of children with a syndrome of seronegative enthesopathy and arthropathy.
    Author: Cabral DA, Oen KG, Petty RE.
    Journal: J Rheumatol; 1992 Aug; 19(8):1282-5. PubMed ID: 1404167.
    Abstract:
    Thirty-six of the 39 children originally described with the syndrome of seronegative enthesopathy and arthropathy, followed for a mean of 11 years after symptom onset, were found to have had a widely varied clinical course. Twelve of the 23 patients (52%) who originally did not have a seronegative spondyloarthropathy developed definite (6) or possible (6) seronegative spondyloarthropathies. The development of a seronegative spondyloarthropathy was associated with HLA-B27 (p = 0.0004) and the presence of arthritis (rather than arthralgia only) at the time of the original report (p = 0.05). For patients with arthritis, the development of a seronegative spondyloarthropathy was associated with arthritis onset after 5 years of age (p = 0.01).
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