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  • Title: EFFECTS OF CERTAIN AMINO ACIDS ON ANTHRANILATE PRODUCTION IN NEUROSPORA CRASSA.
    Author: SOBOREN J, NYC JF.
    Journal: J Bacteriol; 1963 Apr; 85(4):881-8. PubMed ID: 14044958.
    Abstract:
    Soboren, Josephine (University of California, Los Angeles) and Joseph F. Nyc. Effects of certain amino acids on anthranilate production in Neurospora crassa. J. Bacteriol. 85:881-888. 1963.-The level of anthranilic acid produced in cultures of a tryptophanless mutant of Neurospora crassa strain C-83 was closely related to the growth response. A good growth response was attained only on supplements which greatly repressed the level of anthranilate accumulated. The improved growth response of strain C-83 to variable levels of tryptophan and to supplements of the amino acids phenylalanine, tyrosine, leucine, and methionine was correlated with a decreased anthranilate production. The inhibitory effect of these supplements on anthranilate production was ascribed to effects on the mechanisms which regulate the formation of anthranilic acid.
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