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  • Title: Analysis of glycated albumin in postmortem blood samples as the diagnostic parameters of diabetes mellitus.
    Author: Akane A, Shiono H, Matsubara K, Tanabe K, Nakamura H, Hasegawa M, Kagawa M.
    Journal: Nihon Hoigaku Zasshi; 1992 Aug; 46(4):237-43. PubMed ID: 1405016.
    Abstract:
    Glycated hemoglobin (GHb), fructosamine and glycated albumin (GA) in hemolytic sera from cadavers were analyzed for the postmortem diagnosis of diabetes mellitus. The levels of GHb and fructosamine were determined by boronate affinity chromatography and colorimetry, respectively. Albumin fraction was isolated from the samples by Affi-Gel Blue affinity chromatography. The glycated and non-glycated molecules were separated by boronate affinity chromatography, and quantitated by bromcresol green method. Fructosamine could not be analyzed from highly hemolytic sera containing more than 10 g/l hemoglobin. In such samples, the levels of GHb and GA were deviated from the standard values, indicating their postmortem degradation. In less hemolytic samples, GA was as informative as GHb and fructosamine for the diagnosis of diabetes mellitus.
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