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  • Title: [A case of acetaminophen-induced pneumonitis].
    Author: Kitaguchi S, Miyazawa T, Minesita M, Doi M, Takahashi K, Yamakido M.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1992 Jul; 30(7):1322-6. PubMed ID: 1405111.
    Abstract:
    A 20-year-old woman took 1.2 g of acetaminophen for toothache. She subsequently developed a dry cough, pyrexia, and dyspnea. Chest X-ray revealed diffuse reticulo-nodular shadows in both lung fields. Broncho-alveolar lavage examination showed a marked increase in the total cell number and an increase in the percentage of eosinophils, neutrophils, and lymphocytes. Because drug-induced pneumonitis was suspected, all drugs were stopped and she was administered methylprednisolone. Consequently her symptoms resolved, and pulmonary function and chest X-ray findings improved remarkably. The lymphocyte stimulation test was positive for Norshin and its acetaminophen element. Based on these findings, the diagnosis of acetaminophen-induced pneumonitis was made. Acetaminophen intoxication is well-known, but to our knowledge this is the first reported case of acetaminophen-induced allergic pneumonitis in Japan.
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