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  • Title: [Effects of prolonged-action nitrates on platelet aggregation and prostaglandin formation].
    Author: Kirichenko LL, Masenko VP, Evdokimova AG, Iunusov MA.
    Journal: Kardiologiia; 1992 Apr; 32(4):8-10. PubMed ID: 1405245.
    Abstract:
    Platelet aggregation and prostaglandin levels were examined in 50 patients with coronary heart disease concurrent with Functional Classes II-III angina who received nitroglycerin-retard (n = 20; Group 1), corovas (n = 20; Group 2), and placebo (n = 10; Group 3). Long-acting nitrates were found to exert a positive action on thrombocytic hemostasis as decreased platelet aggregation and reverse aggregation in 25% of the corovas-treated patients. Placebo failed to have the same action. Nitroglycerin-retard caused an increase in prostacyclin concentrations. Nitroglycerin-retard and corovas produced a clear-cut antianginal effect. They promoted the reduction in the number of anginal episodes and of nitroglycerin tablets used. No antianginal effect was absent when placebo was used.
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