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  • Title: Immune-complex glomerulonephritis in a patient with mixed connective tissue disease.
    Author: Fuller TJ, Richman AV, Auerbach D, Alexander RW, Lottenberg R, Longley S.
    Journal: Am J Med; 1977 May; 62(5):761-4. PubMed ID: 140604.
    Abstract:
    Renal involvement and hypocomplementemia in mixed connective tissue disease are reported to be rare. A patient is described here with mixed connective tissue disease and persistently low serum C'3 levels in whom renal insufficiency and nephrotic syndrome developed secondary to immune-complex glomerulonephritis. Light microscopy of the renal biopsy specimen showed predominantly a membranous lesion. Immunofluorescent staining showed granular deposition along the basement membrane of immunoglobulin G, immunoglobulin M, fibrinogen and C3. Electron microscopy showed numerous electron-dense deposits along the glomerular capillary membrane and in the mesangium.
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