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  • Title: Transmural distribution of myocardial blood flow and of coronary reserve in canine left ventricular hypertrophy.
    Author: Holtz J, Restorff WV, Bard P, Bassenge E.
    Journal: Basic Res Cardiol; 1977; 72(2-3):286-92. PubMed ID: 140675.
    Abstract:
    Left ventricular hypertrophy was induced by banding of the ascending aorta in pupies at the age of 6 weeks. At the age of one year left ventricular weight per body weight was increased by 87% compared to control litter mates. While myocardial perfusion and myocardial oxygen consumption per 100 g were identical in the hypertrophy and control group, there was a significantly diminshed ratio of subendocardial/subepicardial flow in the hypertrophy group during moderate exercise. With maximal coronary dilation subendocardial diastolic resistance (mm Hg/ml-min-1 per 100 g) was 0.16 +/- 0.03 in the control group and 0.26 +/- 0.03 in the hypertrophy group. This diminished coronary reserve indicates an insufficient growth of the vascular bed in these hypertrophied hearts.
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