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  • Title: Ultrastructural evidence for GABA-mediated disinhibitory circuits in the spinal cord of the cat.
    Author: Liu H, Llewellyn-Smith IJ, Pilowsky P, Basbaum AI.
    Journal: Neurosci Lett; 1992 Apr 13; 138(1):183-7. PubMed ID: 1407660.
    Abstract:
    The synaptic relationships between gamma-aminobutyric acid (GABA)-immunoreactive and enkephalin-immunoreactive profiles in the cat spinal cord were examined using combined pre-embedding immunoperoxidase and post-embedding immunogold electron microscopic immunocytochemistry. Although colchicine was not used, enkephalin-immunoreactive somata and dendrites were detected in regions associated with nociceptive transmission, including laminae I, II, V and X. In each of these laminae, many GABA-immunoreactive terminals were found presynaptic to enkephalin-immunoreactive cell bodies and dendrites. We propose that disinhibition of opioid-containing neurons may be a common feature of pain-related circuits in the cat spinal cord.
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