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  • Title: THYMINE DIMERS AND INHIBITION OF DNA SYNTHESIS BY ULTRAVIOLET IRRADIATION OF CELLS.
    Author: SETLOW RB, SWENSON PA, CARRIER WL.
    Journal: Science; 1963 Dec 13; 142(3598):1464-6. PubMed ID: 14077026.
    Abstract:
    Measurements of the inhibition of DNA synthesis in bacteria and the formation of thymine dimers by ultraviolet irradiation of the cells indicate that one thymine dimer per 350-IA strand of DNA acts as a block to further synthesis. In a sensitive strain of Escherichia coli the blocks are permanent. In a resistant strain the blocks are only temporary but recovery of synthesis is not the result of splitting dimers.
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