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  • Title: Involvement of a receptor for neurite outgrowth factor (NOFR) in cerebellar neurogenesis.
    Author: Kato S, Taniura H, Taira E, Miki N.
    Journal: Neurosci Lett; 1992 Jun 08; 140(1):78-80. PubMed ID: 1407705.
    Abstract:
    A receptor for neurite outgrowth factor (82 kDa membrane protein, NOFR) was detected in the developing chick cerebellum by immuno- and ligand blots. In immunohistochemical study, NOFR was maximally expressed in the external granular layer of cerebellum at embryonic day 10-12 and gradually decreased until embryonic day 18. Neurite outgrowth and cell migration induced by NOF from cerebellar explants were completely suppressed by the addition of anti-NOFR IgG. These results suggest that NOFR plays an important role in the cerebellar neurogenesis.
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