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  • Title: 2,4-DINITROPHENOL: LACK OF INTERACTION WITH HIGH-ENERGY INTERMEDIATES OF OXIDATIVE PHOSPHORYLATION.
    Author: EISENHARDT RH, ROSENTHAL O.
    Journal: Science; 1964 Jan 31; 143(3605):476-7. PubMed ID: 14080313.
    Abstract:
    If the uncoupling agent 2,4-dinitrophenol is added just prior to addition of the phosphate acceptor adenosine diphosphate to rat liver mitochondria previously incubated with substrate, orthophosphate, and oxygen, steady-state phosphorylation is abolished, whereas the initial phase of rapid phosphorylation, the so-called "adenosine triphosphate jump," is undisturbed. This leads to the conclusion that uncoupling agents operate by interfering with the synthesis of high-energy intermediates, not by hydrolyzing or otherwise inactivating them.
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