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  • Title: C-receptor ligand blocks pulmonary clearance of atrial natriuretic peptide in isolated rat lungs.
    Author: Klinger JR, Moalli R, Warburton RR, Wrenn DS, Hill NS.
    Journal: Proc Soc Exp Biol Med; 1992 Nov; 201(2):154-8. PubMed ID: 1409730.
    Abstract:
    Pulmonary clearance of atrial natriuretic peptide (ANP) was measured by indicator dilution technique in isolated perfused rat lungs with and without ANP clearance receptor (C-receptor) blockade. Approximately 50% of a bolus injection of 125I-ANP was removed during a single pass through the lungs compared with the intravascular marker 14C-dextran. Pulmonary clearance of 125I-ANP was suppressed in a dose-dependent fashion by unlabeled ANP. C-receptor blockade suppressed pulmonary clearance of 125I-ANP to the same degree as unlabeled ANP. High-performance liquid chromatography analysis of the pulmonary venous effluent from lungs treated with C-receptor ligand demonstrated intact 125I-ANP. We conclude that virtually all of the pulmonary vascular uptake of 125I-ANP during a single pass through isolated lungs is secondary to removal by ANP C-receptors.
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