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  • Title: Clozapine increases breaking points on a progressive-ratio schedule reinforced by intravenous cocaine.
    Author: Loh EA, Fitch T, Vickers G, Roberts DC.
    Journal: Pharmacol Biochem Behav; 1992 Jul; 42(3):559-62. PubMed ID: 1409791.
    Abstract:
    The effect of the atypical neuroleptic clozapine on cocaine self-administration reinforced on a progressive-ratio schedule in rats was examined. The rat's first response on a lever each day produced an IV infusion of cocaine (0.6 mg/injection) after which the requirements of the schedule escalated with each infusion until the frequency of responding on the lever fell below a criterion level. The final ratio completed was defined as the breaking point. Doses of 5 and 20 mg/kg clozapine produced either no effect or a nonspecific disruption in responding. Rats pretreated with 10 mg/kg clozapine responded to significantly higher breaking points, indicating an increased motivation to self-administer cocaine.
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