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  • Title: [The inhibition by the tumor necrosis factor of the death and DNA fragmentation of lymphoid cells in irradiated rats].
    Author: Proskuriakov SIa, Ivannik BP, Aleksandrova SE, Sin'kova RV, Degtiareva EA, Riabchenko NI.
    Journal: Radiobiologiia; 1992; 32(4):516-21. PubMed ID: 1410288.
    Abstract:
    The influence of a tumor necrosis factor, administered 16 h before irradiation of rats, on the radiation response of thymus and bone marrow cells has been investigated. Three and 6 h after irradiation the following indices were analyzed: the number of apoptotic cells in the thymus; the accumulation of polydeoxyribonucleotides and the appearance of single-strand breaks in DNA of bone marrow and thymus cells; and the electrophoretic properties of thymocyte DNA. The injection of a tumor necrosis factor reduced the number of polydeoxyribonucleotides, inhibited internucleosome DNA fragmentation, and did not influence the formation of single-strand breaks in DNA.
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