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  • Title: [Rhabdomyolysis caused by simvastatinin a patient following heart transplantation and cyclosporine therapy].
    Author: Blaison G, Weber JC, Sachs D, Korganow AS, Martin T, Kretz JG, Pasquali JL.
    Journal: Rev Med Interne; 1992; 13(1):61-3. PubMed ID: 1410877.
    Abstract:
    Hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are cholesterol-lowering agents which may induce rhabdomyolysis. The authors present a case of rhabdomyolysis attributed to simvastatin in a heart-transplant recipient. They stress the probability of a dose-dependent muscular toxicity and the risk of overdosage in patients already under treatment with drugs that interfere with the pharmacokinetics of HMG-CoA reductase inhibitors, notably ciclosporine.
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