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  • Title: E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.
    Author: Nevins JR.
    Journal: Science; 1992 Oct 16; 258(5081):424-9. PubMed ID: 1411535.
    Abstract:
    The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.
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