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  • Title: [RNA and protein metabolism in the myocardium in aging and long-term hyperfunction of the heart].
    Author: Meerson FZ, Iavich MP, Lerman MI.
    Journal: Vopr Med Khim; 1976; 22(6):753-8. PubMed ID: 141167.
    Abstract:
    Metabolism RNA and proteins was distinctly altered in myocardium hypertrophied due to prolonged hyperfunction and in the heart muscle of aged rats. The following alterations were observed: decrease in RNA concentration and in the absolute rate of protein synthesis in vivo, decrease in incorporation of labelled amino acids into heart ribosomes in cell-free system, the distinct depression of RNA turnover. The data obtained suggest that prolonged heart hyperfunction and hypertrophy promote the myocardium impairment and hence the process of senescence in developed more rapidly than under normal conditions.
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