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Title: A clinical and histopathological study of François-Neetens speckled corneal dystrophy. Author: Nicholson DH, Green WR, Cross HE, Kenyon KR, Massof D. Journal: Am J Ophthalmol; 1977 Apr; 83(4):554-60. PubMed ID: 141212. Abstract: A 57-year-old black man had François-Neetens speckled dystrophy of the cornea and orbital phycomycosis. Examination of family members confirmed an auto-somal-dominant pattern of inheritance. Light and electron microscopic study of the cornea of a blind eye disclosed that the corneal opacities were represented by swollen, vacuolated keratocytes filled with histochemically demonstrable acid mucopolysaccharide and complex lipids. Thus, this dystrophy may represent a dominantly inherited metabolic disorder confined to the cornea.[Abstract] [Full Text] [Related] [New Search]