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  • Title: Accuracy of the results measured by in vivo 1H-MRS using model solutions.
    Author: Miyoshi H, Harada M, Moribe T, Nishitani H.
    Journal: Tokushima J Exp Med; 1992 Jun; 39(1-2):63-7. PubMed ID: 1412454.
    Abstract:
    In in vivo 1H-MRS of human brain, main three metabolites such as N-acetyl-L-aspartate (NAA), creatine/phosphocreatine (PCr/Cr), and choline (Cho) have been observed. In this paper an accuracy of the results measured by in vivo 1H-MRS using above model solutions was discussed. 1.0 mmol/l choline and 1.5 mmol/l creatine/phosphocreatine saline solutions were measured with STEAM method (echo time 270 msec). The peak area of Cho was larger than that of PCr/Cr against their concentrations and was linearly increased with its concentration in the range of 5.8 and 29 mumol/27 cm3. Although both peak areas of Cho and Cr/PCr were varied with Volume-of-interest (VOI) coordinates, the ratio of Cho to PCr/Cr was approximately 1.6.
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