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  • Title: [Plasticity of blood vessels of the heart and lungs in collateral circulation under conditions of high altitude].
    Author: Leĭtes AL, Shidakov IuKh, Mameto AM, Isaev AI.
    Journal: Arkh Anat Gistol Embriol; 1976 Dec; 71(12):22-9. PubMed ID: 141248.
    Abstract:
    The combination of the collateral blood flow in the heart and lungs with effects of Alpine hypoxia and pronounced additional loads was found to allow the detecting of plastical capacities of these organs in a sufficiently full volume. The experiments were performed in 273 dogs by microscopic, macro-microscopic, macroscopic and partly functional methods. The collateral coronary blood flow (after ligation of the anterior interventricular artery) under Alpine conditions (3200 m over the sea level) combined with compensatory hyperfunction of the heart (due to stenosing of the aorta arc), gets worse as compared with the conditions of the valley. In these experiments in mountains the extra- and intraorganic anastomoses are more pronounced, the capacity of the coronary artery branches being less pronounced than in the valley. The muscle fibres grow thicker, the heart weight enlarges, the diffusion distances of capillaries increase and the ratio of the arterial bed capacity and the heart weight decreases. Under Alphine conditions (as compared with the valley) the collateral blood flow of lungs deteriorates (after ligation of two lobar branches of the pulmonary artery or of the lobar vein) against the background of additional loads (stenosing of the aorta arc or pulmonectomy). Deterioration of the collateral bloodflow is related with the combination of conditions of the alphine hypoxia with additional loads resulting in a weakening or even block of compensatory reactions of pulmonary or bronchial arteries and veins.
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