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  • Title: SULFONAMYL DIURETICS--MECHANISM OF ACTION AND THERAPEUTIC USE.
    Author: ROBERTS KE.
    Journal: Calif Med; 1964 Mar; 100(3):160-4. PubMed ID: 14131396.
    Abstract:
    The mechanism whereby sulfonamyl diuretics are effective is through the blockage of the renal tubular reabsorption of chloride. The excretion of sodium, potassium and water is a passive one to maintain ionic equilibrium. Chlorothiazide has been shown to be almost ineffective as a diuretic agent per se. Although it does block a moiety of the renal tubular reabsorption of bicarbonate, the effect is merely a transient one.
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