These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.
    Author: Verbiest HB, Straver JS, Colombo JP, van der Vijver JC, van Woerkom TC.
    Journal: Acta Neurol Scand; 1992 Sep; 86(3):275-9. PubMed ID: 1414247.
    Abstract:
    Valproic acid induced coma is presented in an adult patient without a history of metabolic disease. Liver biopsy revealed a reduction in activity of carbamyl phosphate synthetase-I, an enzyme obligated for transformation of ammonia to urea in the urea cycle. After recovery CT scan follow-up showed marked cerebral atrophy which did not exist prior to the state of coma. Risk factors are discussed.
    [Abstract] [Full Text] [Related] [New Search]