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  • Title: [Studies on the alkaloids of Cephalotaxus. IX. Semi-synthesis of cephalotaxine esters and their anti-leukemic activity].
    Author: Wang DZ, Ma GE, Xu RS.
    Journal: Yao Xue Xue Bao; 1992; 27(3):178-84. PubMed ID: 1414382.
    Abstract:
    Harringtonine, homoharringtonine, deoxyharringtonine and isoharringtonine isolated from Cephalotaxus plant are the esters of cephalotaxine with significant inhibitory activity against P-388 leukemia. In this investigation seventeen new esters of cephalotaxine type alkaloids have been synthesized. Preliminary pharmacological examination showed that compounds 1, 2, 2 + 3, 6 and 8 showed similar antileukemic activity as homoharringtonine. Compounds 4, 5, 15 and 16 showed moderate inhibitory activity. Some structure activity correlations of these esters were discussed.
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