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  • Title: [The intratympanic treatment of Menière's disease with ototoxic antibiotics. A follow-up study of 55 cases (author's transl)].
    Author: Lange G.
    Journal: Laryngol Rhinol Otol (Stuttg); 1977 May; 56(5):409-14. PubMed ID: 141554.
    Abstract:
    Report about 55 patients suffering from severe unilateral Menières disease, seen over a period of 3-10 years. They were treated with intratympanic administration of Streptomycinesulfate or- better -Gentamycinesulfate. The medication was given using a plastic tube inserted behind the annulus by transmeatal approach. 0.1 ml Gentamycinesulfate (earlier Streptomycinesulfate were instillated every 5 hours until the first signs of inner-ear-reaction (nystagmus or vertigo) appeared. -In 90% of the cases vertiginous attacks ceased after therapy. Hearing was preserved in 76%, tinnitus and periaural pressure were influenced markedly.
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