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  • Title: POLIOVIRUS: GUANIDINE DEPENDENCE AND LOSS OF NEUROVIRULENCE FOR MONKEYS.
    Author: LODDO B, BROTZU G, SPANEDDA A, GESSA GL, FERRARI W.
    Journal: Science; 1964 Aug 28; 145(3635):945-6. PubMed ID: 14163823.
    Abstract:
    Guanidine-dependent polioviruses are obtained in vitro by subculturing Brunenders, Mahoney, and Sabin strains in the presence of increasing concentrations of guanidine. Mahoney viruses dependent on guanidine lose virulence (as indicated by paralysis) for monkeys inoculated intramuscularly or intracerebrally. Protection against virulent Mahoney viruses is induced by treatment with guanidine-dependent strains, and serum antibodies against the virulent strains are present in the treated animals
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